Acute toxicity and radioprotective effects of amifostine (WR-2721) or cystamine in single whole body fission neutrons irradiated rats
نویسندگان
چکیده
University od South Bohemia, Faculty of Health and Social Studies, Department of Radiology and Toxicology, České Budějovice, Czech Republic, Purkyně Military Medical Academy, Department of Radiobiology, Hradec Králové, Czech Republic, Faculty Hospital, Clinic of Radiation Oncology, Hradec Králové, Czech Republic, Charles University, 2 Medical Faculty, Department of Biophysics and Nuclear Medicine, Praha, Czech Republic, National Authority for Nuclear Safety, Praha, Czech Republic, Charles University, 1 Medical Faculty, Department of Biophysics and Nuclear Medicine, Praha, Czech Republic, Institute of Nuclear Research, Řež u Prahy, Czech Republic, Institute of Nuclear Physics, Academy of Sciences of Czech Republic, Praha, Czech Republic
منابع مشابه
Investigation of the protective effects of melatonin, amifostine (WR-2721), and N-acetylcysteine on radiotherapy-induced uterine tissue injury in rats
Background: The aim of this study was to investigate the protective potency of melatonin, amifostine (WR-2721), and N-acetylcysteine (NAC) when administered intraperitoneally (i.p.) 15 min before 10-Gy single-fraction radiotherapy. Materials and Methods: In this study, 35 female Sprague Dawley rats were divided into five groups of seven rats each. The rats in the control group did not receive a...
متن کاملThe effect of N-acetylcysteine on biomarkers for radiation-induced oxidative damage in a rat model.
Our study aimed to investigate the potential radioprotective effects of N-acetylcysteine (NAC) by comparing its biochemical effects with those of WR-2721, as a representative of clinically used radioprotectors, in preventing oxidative damage caused by gamma irradiation (single dose, 6Gy) in normal rat tissue. The rats (n=40) were divided randomly and equally into 4 groups:Control (C), Radiation...
متن کاملRadiation-induced acute kidney toxicity: Protective effect of L-carnitine versus amifostine
Background: The aim of the study was to compare the radioprotective efficacy in the kidney of L-carnitine to that of amifostine. Materials and Methods: Thirty three-month-old Wistar albino rats were randomly assigned to four groups: Group 1 (Control); Group 2 (Irradiation alone); Group 3 (amifostine plus irradiation); and Group 4 (L-carnitine before irradiation). The rats in Groups 2, 3, ...
متن کاملRadioprotective effects of Sipunculus nudus L. polysaccharide combined with WR-2721, rhIL-11 and rhG-CSF on radiation-injured mice
This study investigated the radioprotective effect of Sipunculus nudus L. polysaccharide (SNP) in combination with WR-2721, rhIL-11 and rhG-CSF on irradiated mice. A total of 70 Imprinting Control Region (ICR) mice were divided into seven groups: the control group, the model group and five administration groups. All groups, except the control group, were exposed to a 5 Gy (60)Co γ-ray beam. Blo...
متن کاملIntraoral manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) radioprotective gene therapy decreases ionizing irradiation-induced murine mucosal cell cycling and apoptosis.
BACKGROUND Single or multiple intraoral administrations of manganese superoxide dismutase-plasmid/liposomes (MnSOD-PL) to C3H/HeNHsd mice receiving single fraction or fractionated ionizing irradiation to the head and neck region have been shown to significantly decrease mucosal ulceration, weight loss and to improve survival. MATERIALS AND METHODS To elucidate the mechanism of irradiation pro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2003